DECENTRALIZED AUTONOMOUS ORGANIZATIONS AS THE NEW FORM OF ECONOMIC COOPERATION IN DIGITAL WORLD


Evaluation of IP3R3 Gene Silencing Effect on Pyruvate Dehydrogenase (PDH) Enzyme Activity in Breast Cancer Cells with and Without Estrogen Receptor

Background: Inositol 1,4,5-trisphosphate Towels receptor (IP3R), a critical calcium ion (Ca2+) regulator, plays a vital role in breast cancer (BC) metabolism.Dysregulated IP3R in BC cells can drive abnormal growth or cell death.Estradiol increases IP3R type 3 (IP3R3) levels in BC, promoting cell proliferation and metabolic changes, including enhanc

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Ubiquitination-mediated Golgi-to-endosome sorting determines the toxin-antidote duality of fission yeast wtf meiotic drivers

Abstract Killer meiotic drivers (KMDs) skew allele transmission in their favor by killing meiotic progeny not inheriting the driver allele.Despite their widespread presence in eukaryotes, the molecular mechanisms behind their selfish behavior are poorly understood.In several fission yeast species, single-gene KMDs belonging to the wtf gene family e

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